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[BLOG] Dengue Fever 101

 
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Since it became a global issue during World War II, researchers and scientists have been struggling to develop a vaccine for Dengue fever.  To date, there has been no success in eradicating this disease.  Before we get to the specifics of the challenges this disease presents, let’s cover the symptoms related to this tropical disease.

DNA Vaccine for Malaria Demonstrates Ability to Kill Infected Cells

 
Anopheles gambiae

A new potential vaccine for malaria is gaining media attention after successful pre-clinical trials in small animals and non-human primates.  Until now, the most effective malaria vaccine in human clinical trials has been GSK’s RTS,S vaccine.  Their vaccine demonstrated a 50% efficacy in children between the ages of 5 and 17 months and only a 30% efficacy in infants aged 6 to 12 weeks.

Brazilian DNA Vaccine for AIDS to be Tested in Rhesus Monkeys

 
AIDS Ribbon

In development since 2001, the HIVBr18 DNA vaccine developed at the Medical School at the University of Sao Paulo (USP) in Brazil may prevent transmission of human immunodeficiency virus (HIV) and development of acquired immune deficiency syndrome (AIDS). 

Combination Cell & Gene Therapy for Brain Metastases of Breast Cancer

 
Brain MRI

New research out of the UCLA Jonsson Comprehensive Cancer Center (JCCC) led by Carol Kruse, professor of neurosurgery, combined two therapies currently undergoing individual clinical trials to determine if the two used in tandem could demonstrate a greater efficacy and reduction of tumor size than either therapy alone.

What Makes VGXI the Best Contract Manufacturing Organization?

 
6th Annual ViE Awards

VGXI was award the Vaccine Industry Excellence (ViE) Award for Best Contract Manufacturing Organization at the 6th Annual ViE Awards Ceremony held at the World Vaccine Congress on April 17th, 2013 in Washington, D.C. 

Cell Line Optimization for DNA Vaccine Production

 
DNA Double Helix Rounded

“Therapeutic plasmid DNA vector” is promising technology for the future of gene therapy. Though still in the clinical trial stage, DNA vaccines have great potential of being successful as effective vaccination technology with negligible side effects.

Low Rates of HPV Vaccination a Result of Parental Fears?

 
CIN 1 HPV Lesion

HPV (Human Papilloma Virus) Vaccines like GARDASIL® (marketed by Merck) and CERVARIX® (marketed by GlaxoSmithKline) have been widely available since 2006 and 2009, respectively. However, in an analysis of national survey data, 40% of parents in 2010 said that they did not intend to have their adolescent daughters vaccinated.

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Writing in a cGMP Environment: Some Tips on Word Usage

 
Woman Typing

 This week’s blog article is geared towards technical writers and those of us who work or operate in a cGMP environment. We are all very familiar with the associated rules and regulations for “appropriate” documentation: not only must everything be documented scrupulously, the way we word our documents also plays a key role in how effective and accurate they are. In honor of all of that, here are some reminders on proper word usage for technical writing; it always helps to refresh our memories from time to time. How else can we ensure we are always staying on top of our game?

DNA Vaccine Delivery Dilemma Solved? Introducing the Painless Patch

 
DNA Vaccine Patch

Scientists have published a new research paper in the journal Nature Materials that demonstrates that through the use of a pain-free microneedle patch, a DNA Vaccine can be delivered over 100 times more effectively than a regular needle injection.

Our Top 5 Most Interesting DNA Vaccine Articles of 2012

 
Needle

Even though 2013 is already under way and there is a constant influx of new information, we wanted to make this an opportunity to look back at 2012 and relive some of our most memorable posts. So here they are, the 5 posts of 2012 that we have deemed the most interesting. Enjoy!

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